OmniBioAI unifies reproducible multi-omics analysis, agentic AI reasoning, and enterprise-grade infrastructure — across local, HPC, and cloud environments.
Grounded in Evidence. A 9-stage retrieval-augmented generation pipeline over 28M+ PubMed abstracts — delivering cited, reproducible answers grounded in published science.
Every component is designed with clinical-grade reliability and reproducibility at its core.
LangGraph-based orchestration with RAG-powered assistants using Hugging Face and Ollama — bridging deterministic bio-computation with explainable AI interpretation.
Native support for WDL, Nextflow, Snakemake, and CWL. Cloud-agnostic Tool Execution Service ensures 1:1 parity between local and massive-scale genomic execution.
Optimized on NVIDIA PyTorch with CUDA on DGX Spark. High-performance GNNs for drug discovery and deep learning for single-cell transcriptomics.
Production-grade Model Registry and LIMS-X metadata system for total traceability — from raw FASTQ to drug-target intelligence and pathway enrichment.
Lab Integrations:
· Benchling (samples, sequences, entities, notebooks)
· REDCap (patient cohorts, clinical research data)
· eLabFTW (experiment export, file upload, tags)
· AWS S3 (import datasets, export results, MinIO compatible)
· Zenodo (publish with DOI, open science, reproducible research)
· LIMS built-in
· ELN-ready export: PDF reports (WeasyPrint) · ELN JSON (machine-readable) · Benchling notebook export · eLabFTW experiment export · CSV/TSV universal format
Sign in with Google, GitHub, or Microsoft, alongside secure email/password authentication via JWT + zero-trust auth service. Existing accounts can link a provider identity with a one-time confirmation step.
90% average test coverage across 28 microservices. Sub-3ms latency for critical service handshakes. Built for clinical-grade stability from day one.
Extensible plugin architecture with OnboardAI documentation browser. 30,000+ lines of living documentation updated after every commit.
Each bioinformatics workflow is modular, allowing researchers to customize, extend, or replace analysis steps without breaking reproducibility.
Runs consistently across local machines, Slurm-based HPC clusters, and cloud platforms like AWS, Azure, and GCP with identical execution logic.
320 Docker images + 1,000 ARM64 SIF images
1,320+ total container images
Available: ghcr.io/omnibioai & huggingface.co/omnibioai
ARM64 + x86_64 support
LangGraph-based agentic workflows dynamically plan, execute, and adapt bioinformatics pipelines, enabling multi-step reasoning across tools, datasets, and analysis stages.
Full-stack error tracking and performance monitoring via Sentry.io across all 28 microservices — with release tracking, error alerting, and performance tracing built in from day one.
WebSocket-based shared workspaces with live chat, object-level comments, annotation history, and full audit trails for reproducible science.
Publish analysis results to Zenodo with automatic DOI generation for citable, reproducible research. Search and import public datasets directly from Zenodo.
Export analysis results directly to eLabFTW electronic lab notebook. Creates experiment entries, uploads output files, and adds tags automatically. Open-source ELN used by thousands of academic labs worldwide.
OmniBioAI's agentic workflows connect research, data, compute, MLOps, cloud infrastructure, and enterprise systems — allowing scientists and AI agents to work across the tools your organization already uses, without leaving the platform.
Search, view, create, update, and comment on ServiceNow incidents via OAuth 2.0 client credentials — manage IT service tickets directly from OmniBioAI.
Access Entra ID users and groups, SharePoint sites and document libraries, Outlook mailbox data, and Teams and channel listings through admin-approved Microsoft Graph access.
Search issues with JQL, create issues, add comments, and transition workflow status directly from OmniBioAI.
Search and retrieve Confluence knowledge, create and update pages, and manage scientific and technical documentation from OmniBioAI.
Connect genomic analysis workflows with AWS HealthOmics, bringing managed bioinformatics workflows and sequencing data processing into OmniBioAI's agentic execution layer.
Connect OmniBioAI agents with cloud infrastructure and services, enabling secure interaction with cloud-native compute, storage, and research environments.
Connect genomic and bioinformatics workflows with DNAnexus for cloud-based data management, analysis, and scalable research execution.
Connect AI agents to Databricks data and analytics environments, enabling research data workflows, SQL analytics, and scalable computational workloads.
Give OmniBioAI workflows controlled access to Snowflake data platforms for querying, analytics, and data-driven scientific workflows.
Connect agents with Git-based development environments to inspect repositories, work with source code, and integrate software development workflows into scientific automation.
Connect experiment tracking and machine-learning lifecycle workflows with MLflow, allowing agents to work with experiments, runs, metrics, parameters, and registered models.
Bring Kubernetes-native compute and orchestration into OmniBioAI, enabling agents to interact with scalable containerized workloads and research infrastructure.
Connect OmniBioAI with the Hugging Face ecosystem for models, datasets, repositories, and AI research workflows — bringing modern machine-learning assets into agentic bioinformatics.
Connect agentic workflows with Apache Airflow for pipeline orchestration, DAG management, monitoring, and automated scientific data workflows.
Bring analytics engineering workflows into OmniBioAI with dbt, enabling agents to work with data transformations, models, documentation, and lineage.
Connect software engineering and DevOps workflows with Azure DevOps, including work items, repositories, pipelines, and project automation.
Connect OmniBioAI agents with Galaxy for reproducible biomedical analysis, workflow execution, tool discovery, and research computing across Galaxy environments.
Connect OmniBioAI agents with Terra for cloud-based genomics and biomedical research, enabling interaction with workspaces, datasets, workflows, and scalable analysis environments.
Connect OmniBioAI agents with Seven Bridges for cloud-based genomic data management, workflow execution, analysis monitoring, and reproducible biomedical research.
Connect sequencing projects, runs, samples, files, and analysis workflows from Illumina BaseSpace with OmniBioAI's agentic research and bioinformatics environment.
Connect OmniBioAI with KNIME scientific and data workflows, enabling agents to discover, execute, monitor, and capture provenance from external analytical workflows.
Import samples, sequences, and research entities directly from Benchling. Export analysis results back as notebook entries and supported Benchling entities, connecting laboratory R&D with computational workflows.
Import authorized research cohorts and study data from REDCap and integrate analysis results back into REDCap projects. Designed for academic medical centers and clinical research workflows.
Import datasets from S3 and export analysis results back to object storage. Supports AWS S3 and compatible storage platforms such as self-hosted MinIO.
From raw sequencing reads to biological insight — OmniBioAI covers the full spectrum of modern genomics.
QC, integration, clustering, trajectory inference, differential expression, TF network modeling, and pathway enrichment.
GATK variant calling, SnpEff annotation, SKAT-O burden testing, NMF, and decile prioritization pipelines.
LEV, SEV, and plasma sample analysis with GSEA, ssGSEA, GSVA, ReactomePA enrichment and volcano plots.
Graph neural networks for drug-target interaction prediction and pathway-level disease modeling.
Patient cohort analysis, variant burden testing, and clinical report generation for precision medicine. REDCap cohort import → multi-omics analysis → results export back to REDCap.
Open chromatin profiling, peak calling, footprinting, and transcription factor binding site analysis.
12 species, pre-indexed and ready. Reference genomes are pre-indexed with STAR, BWA, Bowtie2, and Bismark. Downloaded and cached automatically on first pipeline run.
| Species | Common Name | Assemblies | Annotations | Use Cases | Indexes |
|---|---|---|---|---|---|
| Homo sapiens | Human | GRCh38, GRCh37, T2T-CHM13 |
GENCODE v44, Ensembl 110, RefSeq | WGS, WES, scRNA, ATAC, clinical | STAR BWA Bowtie2 Salmon CellRanger |
| Mus musculus | Mouse | GRCm39, mm10 | GENCODE M33, Ensembl 110 | Drug discovery, knockout models | STAR BWA Bowtie2 Salmon CellRanger |
| Rattus norvegicus | Rat | mRatBN7.2 | Ensembl 110, RefSeq | Pharmacology, toxicology | STAR BWA Bowtie2 Salmon CellRanger |
| Pan troglodytes | Chimpanzee | Pan_tro_3.0 | Ensembl 112 | Comparative genomics, evolution, primate research | STAR BWA Bowtie2 Salmon CellRanger |
| Macaca mulatta | Rhesus Macaque | Mmul_10 | Ensembl 110, RefSeq | Primate translational research | STAR BWA Bowtie2 Salmon CellRanger |
| Danio rerio | Zebrafish | GRCz11 | Ensembl 110, ZFIN | Developmental biology, screens | STAR BWA Bowtie2 Salmon CellRanger |
| Drosophila melanogaster | Fruit Fly | dm6 | FlyBase r6.54, Ensembl | Genetics, CRISPR screens | STAR BWA Bowtie2 Salmon CellRanger |
| Saccharomyces cerevisiae | Yeast | R64-1-1, S288C | SGD, Ensembl Fungi | Yeast two-hybrid, metabolomics | STAR BWA Bowtie2 Salmon CellRanger |
| Caenorhabditis elegans | C. elegans | WBcel235 | WormBase WS290, Ensembl 112 | Aging, longevity, RNAi screens, neuroscience | STAR BWA Bowtie2 Salmon CellRanger |
| Arabidopsis thaliana | Thale Cress | TAIR10 | TAIR 10.1, Ensembl Plants 59 | Plant biology, epigenomics, stress response | STAR BWA Bowtie2 Salmon CellRanger |
| Sus scrofa | Pig | Sscrofa11.1 | Ensembl 112 | Xenotransplantation, cardiovascular, metabolic disease | STAR BWA Bowtie2 Salmon CellRanger |
| Gallus gallus | Chicken | GRCg7b | Ensembl 112 | Immunology, developmental biology, vaccine research | STAR BWA Bowtie2 Salmon CellRanger |
OmniBioAI Studio runs on any modern Linux or macOS machine with Docker installed. One download, no command line needed.
Minimum: 16 GB RAM
Recommended: 32 GB RAM
With local LLM: 64 GB RAM
AppImage / DMG: ~84 MB
Docker images: ~5 GB (one-time pull)
Data + work dirs: 50–200 GB
Linux: Ubuntu 20.04+ (AppImage)
macOS: 12+ Apple Silicon + Intel
Windows: WSL2 + Docker
Docker Engine 24+ or Docker Desktop
Docker Compose v2 (included)
No other dependencies required
NVIDIA GPU + nvidia-container-toolkit
Required only for local LLM inference
Cloud API (Claude/GPT) works without
Internet required for first boot only
~10 GB pulled from ghcr.io automatically
Fully offline after first run
30-day free trial included
License key with every download
7-day offline grace period
[email protected]
Required: sudo apt install jq
Or: brew install jq
Used for health checks and config
Included in most Linux distros
Approved researchers receive a platform-specific download link and onboarding support within 1–2 business days.
↗ Request Beta AccessLicense key included · 30-day free trial
Choose your platform and architecture. All installers include a 30-day free trial license.
Any ARM64 Linux
aarch64
A containerized, microservices-led environment built for massive scale, traceability, and high performance.
OmniBioAI Studio separates user experience orchestration from heavy-lifting workflow engines. It executes multi-omics routines natively, passing biological insights directly into automated reporting and visualization pipelines.
With strict isolation across its core service layers, researchers can safely deploy pipelines locally or easily burst to Slurm or cloud systems without code modifications.
↗ See live architecture & healthMethods developed and powered by OmniBioAI platform architectures across transcriptomics and proteomics.
Get access to OmniBioAI Studio v0.7.0-beta. Accelerate your multi-omics data integration with robust, explainable AI workflows.