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Private beta — now accepting researchers

AI native platform for multi-omics research

OmniBioAI unifies reproducible multi-omics analysis, agentic AI reasoning, and enterprise-grade infrastructure — across local, HPC, and cloud environments.

↗ Request Access ▶ Watch Demo 🌐 Try Web App
15,000+Tools
600+Workflows
300+Plugins
1,120+Containers
10+Agentic Pipelines
28Microservices
28M+Abstracts
150+Domains
12Organisms
Live platform metrics & health →

// Biomedical AI — Literature Intelligence

Powered by PubMed.
Enhanced by AI.

Grounded in Evidence. A 9-stage retrieval-augmented generation pipeline over 28M+ PubMed abstracts — delivering cited, reproducible answers grounded in published science.

01
User Query Natural language or structured biomedical question input
02
Query Expansion (LLM) Synonyms, MeSH terms, and related concepts added via LLM reformulation
03
Hybrid Retrieval (FAISS + BM25) Dense vector search (PubMedBERT embeddings) merged with sparse BM25 keyword retrieval
04
Reciprocal Rank Fusion (RRF) Dense and sparse result lists merged and re-scored by RRF for unified ranking
05
Cross-Encoder Re-ranking PubMedBERT cross-encoder re-scores top-k candidates for precision retrieval
06
Citation Confidence Scoring Papers weighted by citation impact, journal tier, recency, and domain relevance
07
Knowledge Graph Enrichment (Neo4j) Entity links — genes, diseases, drugs, pathways — resolved via Neo4j biomedical KG traversal
08
LLM Reasoning (DeepSeek-R1) Evidence chains synthesized with explicit chain-of-thought reasoning and full citation anchoring
09
Structured Output (PMIDs + Evidence + Entities) PMIDs + evidence snippets + named entities + confidence scores returned as structured JSON
28M PubMed abstracts indexed and searchable
150+ Biomedical domains covered
<30s Query response time end-to-end
9-stage Pipeline with full citation provenance
PubMedBERT embeddings Neo4j knowledge graph Hybrid BM25 + FAISS DeepSeek-R1 reasoning Cross-encoder re-ranking Reciprocal Rank Fusion Citation confidence scoring MeSH query expansion Structured JSON output PMID-anchored evidence Named entity extraction Local · air-gapped · private

// Core capabilities

Built for real science,
not demos

Every component is designed with clinical-grade reliability and reproducibility at its core.

Agentic AI reasoning

LangGraph-based orchestration with RAG-powered assistants using Hugging Face and Ollama — bridging deterministic bio-computation with explainable AI interpretation.

Workflow agnostic

Native support for WDL, Nextflow, Snakemake, and CWL. Cloud-agnostic Tool Execution Service ensures 1:1 parity between local and massive-scale genomic execution.

GPU-accelerated stack

Optimized on NVIDIA PyTorch with CUDA on DGX Spark. High-performance GNNs for drug discovery and deep learning for single-cell transcriptomics.

End-to-end provenance

Production-grade Model Registry and LIMS-X metadata system for total traceability — from raw FASTQ to drug-target intelligence and pathway enrichment.

Lab Integrations:
· Benchling (samples, sequences, entities, notebooks)
· REDCap (patient cohorts, clinical research data)
· eLabFTW (experiment export, file upload, tags)
· AWS S3 (import datasets, export results, MinIO compatible)
· Zenodo (publish with DOI, open science, reproducible research)
· LIMS built-in
· ELN-ready export: PDF reports (WeasyPrint) · ELN JSON (machine-readable) · Benchling notebook export · eLabFTW experiment export · CSV/TSV universal format

🔐
SSO Support

Sign in with Google, GitHub, or Microsoft, alongside secure email/password authentication via JWT + zero-trust auth service. Existing accounts can link a provider identity with a one-time confirmation step.

Reliability-first design

90% average test coverage across 28 microservices. Sub-3ms latency for critical service handshakes. Built for clinical-grade stability from day one.

Plugin ecosystem

Extensible plugin architecture with OnboardAI documentation browser. 30,000+ lines of living documentation updated after every commit.

Modular pipeline system

Each bioinformatics workflow is modular, allowing researchers to customize, extend, or replace analysis steps without breaking reproducibility.

Cloud & HPC ready

Runs consistently across local machines, Slurm-based HPC clusters, and cloud platforms like AWS, Azure, and GCP with identical execution logic.

🐳
Docker Images

320 Docker images + 1,000 ARM64 SIF images
1,320+ total container images
Available: ghcr.io/omnibioai & huggingface.co/omnibioai
ARM64 + x86_64 support

🤖
Agentic workflow orchestration

LangGraph-based agentic workflows dynamically plan, execute, and adapt bioinformatics pipelines, enabling multi-step reasoning across tools, datasets, and analysis stages.

🛡
Production-Grade Observability

Full-stack error tracking and performance monitoring via Sentry.io across all 28 microservices — with release tracking, error alerting, and performance tracing built in from day one.

Real-Time Collaboration

WebSocket-based shared workspaces with live chat, object-level comments, annotation history, and full audit trails for reproducible science.

🎓
Zenodo Integration

Publish analysis results to Zenodo with automatic DOI generation for citable, reproducible research. Search and import public datasets directly from Zenodo.

📓
eLabFTW Integration

Export analysis results directly to eLabFTW electronic lab notebook. Creates experiment entries, uploads output files, and adds tags automatically. Open-source ELN used by thousands of academic labs worldwide.


// Enterprise & scientific workflow integrations

Scientific work,
connected across your stack

OmniBioAI's agentic workflows connect research, data, compute, MLOps, cloud infrastructure, and enterprise systems — allowing scientists and AI agents to work across the tools your organization already uses, without leaving the platform.

🎫
ServiceNow Integration

Search, view, create, update, and comment on ServiceNow incidents via OAuth 2.0 client credentials — manage IT service tickets directly from OmniBioAI.

🪟
Microsoft Graph Integration

Access Entra ID users and groups, SharePoint sites and document libraries, Outlook mailbox data, and Teams and channel listings through admin-approved Microsoft Graph access.

📋
Jira Integration

Search issues with JQL, create issues, add comments, and transition workflow status directly from OmniBioAI.

📚
Confluence Integration

Search and retrieve Confluence knowledge, create and update pages, and manage scientific and technical documentation from OmniBioAI.

🧬
AWS HealthOmics Integration

Connect genomic analysis workflows with AWS HealthOmics, bringing managed bioinformatics workflows and sequencing data processing into OmniBioAI's agentic execution layer.

☁️
Cloud Integration

Connect OmniBioAI agents with cloud infrastructure and services, enabling secure interaction with cloud-native compute, storage, and research environments.

🔬
DNAnexus Integration

Connect genomic and bioinformatics workflows with DNAnexus for cloud-based data management, analysis, and scalable research execution.

🧪
Databricks Integration

Connect AI agents to Databricks data and analytics environments, enabling research data workflows, SQL analytics, and scalable computational workloads.

❄️
Snowflake Integration

Give OmniBioAI workflows controlled access to Snowflake data platforms for querying, analytics, and data-driven scientific workflows.

🐙
Git Hosting Integration

Connect agents with Git-based development environments to inspect repositories, work with source code, and integrate software development workflows into scientific automation.

📈
MLflow Integration

Connect experiment tracking and machine-learning lifecycle workflows with MLflow, allowing agents to work with experiments, runs, metrics, parameters, and registered models.

☸️
Kubernetes Integration

Bring Kubernetes-native compute and orchestration into OmniBioAI, enabling agents to interact with scalable containerized workloads and research infrastructure.

🤗
Hugging Face Integration

Connect OmniBioAI with the Hugging Face ecosystem for models, datasets, repositories, and AI research workflows — bringing modern machine-learning assets into agentic bioinformatics.

🌬️
Apache Airflow Integration

Connect agentic workflows with Apache Airflow for pipeline orchestration, DAG management, monitoring, and automated scientific data workflows.

🛠️
dbt Integration

Bring analytics engineering workflows into OmniBioAI with dbt, enabling agents to work with data transformations, models, documentation, and lineage.

🔷
Azure DevOps Integration

Connect software engineering and DevOps workflows with Azure DevOps, including work items, repositories, pipelines, and project automation.

🌌
Galaxy Integration

Connect OmniBioAI agents with Galaxy for reproducible biomedical analysis, workflow execution, tool discovery, and research computing across Galaxy environments.

🌍
Terra Integration

Connect OmniBioAI agents with Terra for cloud-based genomics and biomedical research, enabling interaction with workspaces, datasets, workflows, and scalable analysis environments.

🧬
Seven Bridges Integration

Connect OmniBioAI agents with Seven Bridges for cloud-based genomic data management, workflow execution, analysis monitoring, and reproducible biomedical research.

🧬
Illumina BaseSpace Integration

Connect sequencing projects, runs, samples, files, and analysis workflows from Illumina BaseSpace with OmniBioAI's agentic research and bioinformatics environment.

🔗
KNIME Integration

Connect OmniBioAI with KNIME scientific and data workflows, enabling agents to discover, execute, monitor, and capture provenance from external analytical workflows.

Benchling Integration

Import samples, sequences, and research entities directly from Benchling. Export analysis results back as notebook entries and supported Benchling entities, connecting laboratory R&D with computational workflows.

REDCap Integration

Import authorized research cohorts and study data from REDCap and integrate analysis results back into REDCap projects. Designed for academic medical centers and clinical research workflows.

☁️
AWS S3 Integration

Import datasets from S3 and export analysis results back to object storage. Supports AWS S3 and compatible storage platforms such as self-hosted MinIO.


// Multi-omics coverage

Every modality,
one platform

From raw sequencing reads to biological insight — OmniBioAI covers the full spectrum of modern genomics.

scRNA-seq
Single-cell transcriptomics

QC, integration, clustering, trajectory inference, differential expression, TF network modeling, and pathway enrichment.

WGS / WES
Whole exome & genome

GATK variant calling, SnpEff annotation, SKAT-O burden testing, NMF, and decile prioritization pipelines.

Proteomics
Protein expression analysis

LEV, SEV, and plasma sample analysis with GSEA, ssGSEA, GSVA, ReactomePA enrichment and volcano plots.

Drug discovery
GNN-based target identification

Graph neural networks for drug-target interaction prediction and pathway-level disease modeling.

Clinical
Translational pipelines

Patient cohort analysis, variant burden testing, and clinical report generation for precision medicine. REDCap cohort import → multi-omics analysis → results export back to REDCap.

ATAC-SEQ
Chromatin accessibility

Open chromatin profiling, peak calling, footprinting, and transcription factor binding site analysis.

ChIP-seq
Protein-DNA interactions

Histone modification and transcription factor binding analysis with peak annotation and motif enrichment.

circRNA
Circular RNA analysis

Detection, quantification, and functional annotation of circular RNAs from RNA-seq data.

RNA-seq
Bulk transcriptomics

Alignment, quantification, differential expression, and pathway analysis for bulk RNA sequencing.

Spatial
Spatial transcriptomics

Spatially resolved gene expression mapping and cell-type deconvolution across tissue sections.

Spatial single-cell
Spatial + single-cell integration

Joint analysis of spatial context and single-cell resolution for deep tissue-level insights.

SV calling
Structural variant detection

Detection and annotation of large-scale genomic rearrangements including inversions, deletions, and translocations.

Methylation
Epigenome methylation pipeline

Bisulfite sequencing → CpG calling → DMR detection → epigenetic age/biomarker analysis.

Multi-omics
Integrated multi-modal analysis

Cross-modality data integration combining genomic, transcriptomic, and epigenomic layers for systems-level insights.

CRISPR
Genome editing & screen analysis

CRISPR screen analysis including guide RNA QC, alignment, indel detection, and editing efficiency scoring.

variant_ml
Variant prioritization ML

Feature engineering + ML ranking of pathogenic variants using phenotype + genomic signals.

LONG-READ
Long-read sequencing

Nanopore and PacBio long-read alignment, assembly, methylation and isoform analysis.

MICROBIOME
Metagenomics

Shotgun metagenomic profiling, taxonomic classification, functional annotation and diversity analysis.

EPIGENOMICS
Epigenome analysis

ChIP-seq, ATAC-seq, methylation and chromatin accessibility across the full epigenome.

PythonRNextflow WDLSnakemakeCWL GATKSeuratDESeq2 LangGraphPyTorchCUDA DockerKubernetesFastAPI DjangoCeleryRedis MySQLAWSAzureGCP SlurmHuggingFaceOllamaSentry BenchlingREDCapeLabFTW AWS S3Zenodo

// Reference genomes

Reference Genomes

12 species, pre-indexed and ready. Reference genomes are pre-indexed with STAR, BWA, Bowtie2, and Bismark. Downloaded and cached automatically on first pipeline run.

Species Common Name Assemblies Annotations Use Cases Indexes
Homo sapiens Human GRCh38, GRCh37,
T2T-CHM13
GENCODE v44, Ensembl 110, RefSeq WGS, WES, scRNA, ATAC, clinical STAR BWA Bowtie2 Salmon CellRanger
Mus musculus Mouse GRCm39, mm10 GENCODE M33, Ensembl 110 Drug discovery, knockout models STAR BWA Bowtie2 Salmon CellRanger
Rattus norvegicus Rat mRatBN7.2 Ensembl 110, RefSeq Pharmacology, toxicology STAR BWA Bowtie2 Salmon CellRanger
Pan troglodytes Chimpanzee Pan_tro_3.0 Ensembl 112 Comparative genomics, evolution, primate research STAR BWA Bowtie2 Salmon CellRanger
Macaca mulatta Rhesus Macaque Mmul_10 Ensembl 110, RefSeq Primate translational research STAR BWA Bowtie2 Salmon CellRanger
Danio rerio Zebrafish GRCz11 Ensembl 110, ZFIN Developmental biology, screens STAR BWA Bowtie2 Salmon CellRanger
Drosophila melanogaster Fruit Fly dm6 FlyBase r6.54, Ensembl Genetics, CRISPR screens STAR BWA Bowtie2 Salmon CellRanger
Saccharomyces cerevisiae Yeast R64-1-1, S288C SGD, Ensembl Fungi Yeast two-hybrid, metabolomics STAR BWA Bowtie2 Salmon CellRanger
Caenorhabditis elegans C. elegans WBcel235 WormBase WS290, Ensembl 112 Aging, longevity, RNAi screens, neuroscience STAR BWA Bowtie2 Salmon CellRanger
Arabidopsis thaliana Thale Cress TAIR10 TAIR 10.1, Ensembl Plants 59 Plant biology, epigenomics, stress response STAR BWA Bowtie2 Salmon CellRanger
Sus scrofa Pig Sscrofa11.1 Ensembl 112 Xenotransplantation, cardiovascular, metabolic disease STAR BWA Bowtie2 Salmon CellRanger
Gallus gallus Chicken GRCg7b Ensembl 112 Immunology, developmental biology, vaccine research STAR BWA Bowtie2 Salmon CellRanger
STAR Available
CellRanger Coming soon

// System requirements

What you need
to get started

OmniBioAI Studio runs on any modern Linux or macOS machine with Docker installed. One download, no command line needed.

💾
Memory

Minimum: 16 GB RAM
Recommended: 32 GB RAM
With local LLM: 64 GB RAM

💿
Storage

AppImage / DMG: ~84 MB
Docker images: ~5 GB (one-time pull)
Data + work dirs: 50–200 GB

🖥️
Operating System

Linux: Ubuntu 20.04+ (AppImage)
macOS: 12+ Apple Silicon + Intel
Windows: WSL2 + Docker

🐳
Docker

Docker Engine 24+ or Docker Desktop
Docker Compose v2 (included)
No other dependencies required

GPU (Optional)

NVIDIA GPU + nvidia-container-toolkit
Required only for local LLM inference
Cloud API (Claude/GPT) works without

🌐
Network

Internet required for first boot only
~10 GB pulled from ghcr.io automatically
Fully offline after first run

🔑
License

30-day free trial included
License key with every download
7-day offline grace period
[email protected]

🧬
jq

Required: sudo apt install jq
Or: brew install jq
Used for health checks and config
Included in most Linux distros

● Private Beta · v0.7.0-beta

Access requires approval

Approved researchers receive a platform-specific download link and onboarding support within 1–2 business days.

↗ Request Beta Access

License key included · 30-day free trial


// Downloads

OmniBioAI Studio
v0.7.0-beta

Choose your platform and architecture. All installers include a 30-day free trial license.

macOS
🍎
Apple Silicon

M1 / M2 / M3 / M4
Native ARM64 build

↓ DMG · 101 MB
💻
Intel Architecture

Legacy Intel Mac
Native x86_64 build

↓ DMG · 105 MB
🐧 Linux x86_64 (Intel / AMD)
📦
AppImage

Any Linux distro
Ubuntu 20.04+

↓ AppImage · 84 MB
📦
DEB Package

Ubuntu / Debian / Mint
amd64

↓ DEB · ~85 MB
sudo dpkg -i omnibioai_*.deb
📦
RPM Package

RHEL / Fedora / CentOS
x86_64

↓ RPM · ~85 MB
sudo rpm -i omnibioai-*.rpm
🦾 Linux ARM64 (DGX / Graviton / Raspberry Pi)
📦
AppImage ARM64

Any ARM64 Linux
aarch64

↓ AppImage · ~80 MB
chmod +x *.AppImage && ./OmniBioAI*.AppImage
📦
DEB ARM64

Ubuntu / Debian ARM64
aarch64

↓ DEB · ~85 MB
sudo dpkg -i omnibioai_*arm64.deb
📦
RPM ARM64

RHEL / Fedora ARM64
aarch64

↓ RPM · ~85 MB
sudo rpm -i omnibioai-*.aarch64.rpm
🪟 Windows (WSL2)
🪟
Windows Installer

Windows 10 / 11 x64
Requires WSL2 Enabled

↓ EXE · ~90 MB

// System architecture

Clinical-grade design

A containerized, microservices-led environment built for massive scale, traceability, and high performance.

Engineered for absolute provenance

OmniBioAI Studio separates user experience orchestration from heavy-lifting workflow engines. It executes multi-omics routines natively, passing biological insights directly into automated reporting and visualization pipelines.

With strict isolation across its core service layers, researchers can safely deploy pipelines locally or easily burst to Slurm or cloud systems without code modifications.

↗ See live architecture & health
OmniBioAI Studio UI (Desktop Frontend)
│ Handshake (sub-3ms latency)
Agentic AI Orchestration (LangGraph / Ollama / HF)
│ Orchestration & data mapping
BioFlow Runtime Engine (Nextflow / WDL / Snakemake)
│ Tracking & provenance link
LIMS-X Metadata & Sample Tracking System
│ Infrastructure layer
GPU Accelerated Stack (CUDA / NVIDIA DGX Spark)

// Academic presence

Peer-reviewed research

Methods developed and powered by OmniBioAI platform architectures across transcriptomics and proteomics.

2025
Genetic mutations in lymphocytic variant of hypereosinophilic syndrome: study of five siblings
Frontiers in Medicine · December 2025
↗ View paper
2018
Whole Exome Sequencing identifies common and rare variant Metabolic QTLs in a Middle Eastern Population
Nature Communications · January 2018
↗ View paper
2015
MetaRNA-Seq: An Interactive Tool to Browse and Annotate Metadata from RNA-Seq Studies
BioMed Research International · August 2015
↗ View paper

// Apply for private beta

Request Access

Get access to OmniBioAI Studio v0.7.0-beta. Accelerate your multi-omics data integration with robust, explainable AI workflows.

🐧 Linux Ubuntu / Debian / RHEL AppImage · 78 MB
🍎 macOS Apple Silicon or Intel DMG · 84 MB
🪟 Windows WSL2 required EXE · ~90 MB